Using a system that analyzes blood samples with unprecedented detail, a team led by Massachusetts General Hospital (MGH) researchers has developed the first "chemical snapshot" of the metabolic effects of exercise. Their findings, reported in the May 26 issue of Science Translational Medicine, may improve understanding of the physiologic effects of exercise and lead to new treatments for cardiovascular disease and diabetes.



"We found new metabolic signatures that clearly distinguish more-fit from less-fit individuals during exercise," says Gregory Lewis, MD, of the MGH Heart Center, the paper's lead author. "These results have implications for the development of optimal training programs and improved assessment of cardiovascular fitness, as well as for the development of nutritional supplements to enhance exercise performance."



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